Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer

Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer

Ohsawa, Kosuke

Springer Verlag, Japan

10/2016

109

Mole

Inglês

9784431562870

15 a 20 dias

2226

Descrição não disponível.
Introduction.- Total Synthesis of Thielocin B1 and NMR Chemical Shift Perturbation Experiments with PAC3 Homodimer.- Synthesis of Spin-labeled Thielocin B1 and Observation of Paramagnetic Relaxation Enhancement Effects.- An Improved Method for the Direct Formylation ob Substituted Benzenes Using Dichloromethyl Methyl Ether-Silver Trifluoromethanesulfonate.- Conclusions.
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2,2',6,6'-Tetrasubstituted Diphenyl Ether;Docking Study;Effects Observation;PPIs;PRE Effects Observation;Paramagnetic Relaxation Enhancement;Proteasome Assembly Chaperone;Protein-protein interactions