Voltage-gated Sodium Channels: Structure, Function and Channelopathies

Preface.- Part I.- Evolution of voltage-gated sodium channels.- 1. Evolutionary History of Voltage-Gated Sodium Channels.- 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function.- 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective.- 4. The Cardiac Sodium Channel and Its Protein Partners.- 5. : Posttranslational Modification of Sodium Channels.- 6. Sodium Channel Trafficking.- 7. pH Modulation of Voltage-Gated Sodium Channels.- 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C.- Part III. Drugs and toxins interactions with sodium channels.- 9. Toxins That Affect Voltage-Gated Sodium Channels.- 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.- 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels.- 12. Structural Models of Ligand-Bound Sodium Channels.- 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7.- Part IV. Pathophysiology of sodium channels.- 14. Sodium Channelopathies of Skeletal Muscle.- 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction.- 16. Translational Model Systems for ComplexSodium Channel Pathophysiology in Pain.- 17. Gating Pore Currents in Sodium Channels.- 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells.- 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases.

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• Genética médica
• Farmacologia
• Fisiologia
• Proteinas

voltage-gated sodiium channels;Biophysics;Channelopathies;Electrophysiology;Pharmacology;Protein Structure