Pathology of Cardiac Transplantation

Introduction.- Cardiac transplantation and the contribution of pathology.- Prior to cardiac transplantation.- Advanced end-stage heart failure: epidemiology and management.- Mechanical circulatory support in end-stage heart failure: bridge to transplantation and destination therapy.- Clinical indications for heart transplantation.- Pathologies encountered in explanted native hearts.- Pre-transplant endomyocardial biopsy: when and why.- Heart donation and peritransplant pathologies.- Donor selection criteria: clinical and pathological insights.- Donor organ harvesting and preservation.- Perioperative damage to the graft.- Post-cardiac transplantation: the multiple faces of rejection.- Clinical management of transplant recipients.- Practical immunology for pathologists.- Pathology of acute cellular rejection.- Pathology of antibody mediated rejection.- Mixed rejection.- Pathological non rejection findings in the endomyocardial biopsy.- Non-invasive tools for monitoring allograft rejection: state of the art.- Cardiac allograft vasculopathy.- Post-cardiac transplantation: complications other than rejection.- Infections.- Tumours.- Chronic kidney disease after heart transplantation: risk factors, clinics and histopathology.- Special issues in cardiac transplantation.- Combined heart transplant.- The autopsy in heart transplantation.- Examining a heart with implantable mechanical circulatory support systems.

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• Imunologia
• Patologia
• Medicina cardiovascular
• Cirurgia cardiotorácica

allograft vasculopathy;endomyocardial biopsy;heart disease;heart donor;rejection