Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering

Introduction.- Lipid bilayers.- Tat peptide.- Pbc ripple phase.- Structural and Material Perturbations of Lipid Bilayers Due to HIV-1 Tat Peptide.- Introduction.- Materials and Methods.- Analysis of Molecular Dynamics Simulation Data.- Results.- Discussion.- Conclusions.- Ripple Phase.- Introduction.- Materials and Methods.- LAXS Data Reduction.- Results for Fhk Form Factors.- Models to Fit the Fhk and Obtain the Phase Factors.- Electron Density Profiles and Coarse Grained Bilayer Structure.- nGIWAXS: Results.- tWAXS: Results.- Thin Rod Model.- Combining WAXS and LAXS Results for the Major Arm.- Discussion.- Conclusion.- Appendices.

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• Química física
• Ensaio de materiais
• Biofísica
• Biologia Celular (citologia)

Bilayer thinning;DMPC ripple phase;Fuid phase membranes;HIV-1 Tat peptide;Lipid bilayers;Molecular dynamics;PB ripple phase;Tat headgroup;Tat protein;WAXS and LAXS;X-ray scattering in biomembranes