Neuroimmune Pharmacology

Preface.- Introduction.- Innate and adaptive Immunity in Health and Disease.- The Blood-Brain Barriers.- Regulation of Nervous System Function by Circumventricular Organs.- Anterior Chamber and Retina (Structure, Function and Immunology).- Hippocampus, Spatial Memory and Neuroimmunomodulation.- Anatomical Networks: Structure and Function of the Nervous System.- Inflammasomes in the Central Nervous System: Immune Sensors and Effectors of Health and Disease.- LRRK2: A Kinase at the Crossroads of Neuroimmune Interactions in the Pathogenesis of Chronic Inflammatory Disease and Parkinson's Disease.- Astrocytes, Oligodendrocytes and Schwann Cells.- Macrophages, Microglia And Dendritic Cells: Biology And Function.- Mononuclear Phagocytes.- Cellular Composition, Biology and Physiology: Microglia.- The Vertebrate Retina.- Human Lymphocyte Biology and Its Application To Humanized Mice.- Stem Cells and Neurogenesis for Brain Development, Degeneration and Therapy.- Innate Immunity Signaling.- Cytokines and Chemokines.- Growth and Neurotrophic Factors for HIV-Associated Neurocognitive Disorders.- RNA Binding Proteins in Health and Disease.- Exosomes and Neuroregulation.- MicroRNA Implications in Neurodegenerative Disorders.- Neurodegeneration.- Multiple Sclerosis: Pathogenesis and Disease Application.- Guillain-Barre, Chronic Inflammatory Demyelinating Polyradiculoneurophathy, and Axonal Degeneration and Regeneration.- Guillian-Barre Syndrome and Acute Neuropathy.- Autoimmunity in Neurologic Disease.- HIV-Associated Neurocognitive Disorders.- Neuroimmunomodulation of Human T-Lymphotrophic Virus Type I/II Infection.- Viral Encephalitis.- Alzheimer's Disease.- Parkinson's Disease.- Neuroinflammation: A Key to Clinical Heterogeneity in Amyotrophic Lateral Sclerosis.- Neuroimmune Response and Inflammation in Huntington's Disease.- Human Prion Diseases.- Glaucoma.- Ocular Manifestations of Systemic Autoimmune Diseases.- Neurogenesis and Brain Repair.- Chronic Traumatic Encephalopathy.- Molecular, Cellular and Physiological Mechanisms of Psychiatric Disorders. The Neuroimmune System in Psychiatric Disorders (Overview).- Autism Spectrum Disorders.- Drugs of Abuse and the Immune System.- Therapeutic Strategies in Neurodegenerative Diseases.- Immunomodulatory Therapy for Multiple Sclerosis.- Therapeutic Considerations in HIV-Associated Neurocognitive Disorders.- Immunotherapy for Alzheimer's Disease.- Immunotherapies for Movement Disorders: Parkinson's Disease and Amyotrophic Lateral Sclerosis.- Regenerative and Repair Strategies for the Central Nervous System.- New Generation of Adjuvants for Protection against Disease and to Combat Bioterrorism.- Medicinal Chemistry and Brain Drug Penetrance.- Polymer Nanomaterials for Drug Delivery Across the Blood Brain Barrier.- Macromolecular Therapeutics - Development and Delivery Engineering.- Application to Gene Therapy and Vaccination.- Introduction to Imaging in the Neurosciences.- Proteomics and Genomics in Neuroimmunological Disorders.- Pharmacogenomics of Neurodegenerative Diseases: Roles in Personalized Medicines.- Conclusion.- Glossary.- Index.

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• Farmacologia
• Imunologia
• Neurociências

health;disease;blood-brain barrier;nervous system;retina;hippocampus;inflammasones;pathogenesis;astrocytes;microglia;signaling;exosomes;neuroregulation;neurodegeneration;autoimmunity;encephalitis;neuroinflammation;glaucoma