Human Neural Stem Cells

Part 1. Derivation and/or generation of human neural stem cells.- 1. Derivation of neural stem cells from the developing and adult human brain.- 2. Comparison of after-birth and adult somatic tissues in ability to generate human neural stem cells.- 3. Neural stem cells derived from human induced pluripotent stem cells and their use in models of CNS injury.- 4. Generation of human neural stem cells by direct phenotypic conversion.- Part 2. Differentiation and underlying mechanisms.- 5. Epigenetic regulation of human neural stem cell differentiation.- 6. Human iPSC-derived neuronal committed cells reveal common developmental genome deprograming in schizophrenia.- 7. Genome editing in human neural stem and progenitor cells.- 8. Brain Organoids - expanding our understanding of human development and disease.- 9. Microenvironmental cues in human neural stem cell fate commitment.- Part 3. Therapeutic potential of human neural stem cells.- 10. Updates on Human Neural Stem Cells: From Generation, Maintenance and Differentiation to Research and Translational Applications.- 11. Human neural stem cells for ischemic stroke treatment.- 12. Modeling pediatric and neuropsychiatric diseases using human iPSC.- 13. Neural stem cell dysfunction in human brain diseases.- 14. Human Fetal Neural Stem Cells for neurodegenerative disease treatment.

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• Neurociências
• Genética médica
• Genética (não médica)
• Terapia genética

human neural stem cells;hNSC;hNSC derivation;hNSC differentiation;hNSC engineering;hNSC clinical application;gene therapy;cytogenetics