Group Sequential and Confirmatory Adaptive Designs in Clinical Trials

Part I Group Sequential Designs.- Repeated Significance Tests: Procedures with Equally Sized Stages.- Procedures with Unequally Sized Stages.- Confidence Intervals, p -Values, and Point Estimation.- Applications.- Part II Adaptive Confirmatory Designs with a Single Hypothesis: Adaptive Group Sequential Tests.- Decision Tools for Adaptive Designs.- Estimation and p-Values for Two-stage Adaptive Designs.- Adaptive Designs with Survival Data.- Part III Adaptive Designs with Multiple Hypotheses: Multiple Testing in Adaptive Designs.- Applications and Case Studies.- Appendix - Software for Adaptive Designs.- Index.

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• Probabilidade e Estatística
• Bioquímica
• Farmacologia

adaptive designs;clinical trials;group sequential designs;multiple hypotheses;sample size