Fibrostenotic Inflammatory Bowel Disease

Foreword.- Fibrostenotic Inflammatory Bowel Disease - a Cinderella story.- Epidemiology and natural history of fibrostenosing IBD.- The genetics of IBD associated fibrosis.- Epigenetic regulation of intestinal fibrosis.- Anti-cytokine or growth factor therapy as a future therapeutic of fibrostenosing IBD.- Inflammation independent mechanisms of intestinal fibrosis.- Environmental factors and their influence on intestinal fibrosis.- Fat and fibrosis.- Sources of mesenchymal cells in intestinal fibrosis.- Animal models of intestinal fibrosis.- Mechanisms of resolution of intestinal fibrosis.- The intestinal mesenchymal cell and extracellular matrix as a pathogenetic factor in inflammation driven intestinal carcinogenesis.- Fibrosis in Ulcerative Colitis.- Histopathology of intestinal fibrosis.- Clinical, Cellular and Serologic Biomarkers of intestinal fibrosis .- Imaging in intestinal fibrosis - What is state or the art?.- The future of intestinal fibrosis imaging.- Medical therapy of stricturing IBD.- Endoscopic therapy of intestinal strictures - What is state of the art?.- The future of endoscopic therapy of intestinal strictures.- Surgical therapy of intestinal strictures - What is state of the art?.- The future of surgical therapy of structuring IBD.- Challenges of translation of anti-fibrotic therapies into clinical practice in IBD.- What distinguishes mechanisms of fistula and stricture formation.- The Pathogenesis of Intraabdominal Adhesions: Similarities and differences to luminal fibrosis.- Anti-fibrotic therapies from other organs - What the gut can learn from the liver, skin, lung and heart.

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• Gastroenterologia
• Patologia
• Cirurgia

fibrostenotic IBD;intestinal strictures;ulcerative colitis;anti-fibrotic therapies;intestinal fibrosis;intestinal ultrasound;strictureplasty;cytokines;extracellular matrix;postoperative fibrosis;Endoscopic balloon dilatation