Druggable Lipid Signaling Pathways

Druggable Lipid Signaling Pathways

Kihara, Yasuyuki

Springer Nature Switzerland AG

09/2021

260

Mole

Inglês

9783030506230

15 a 20 dias

609

Descrição não disponível.
Preface.- Introduction of Druggable Lipid Signaling Pathway.- Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development.- Druggable Prostanoid Pathway.- Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic Stress.- Epoxy Fatty Acids are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation.- Druggable Sphingolipid Pathway.- Druggable Lysophospholipid Pathway.- Druggable targets in endocannabinoid signaling.- Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections.- Druggable Lipid GPCRs: Past, Present, and Prospects.

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lipids;GPCR;drug discovery;disease;translational research