DNA Methyltransferases - Role and Function

Mechanisms and biological roles of DNA methylation and DNA methyltransferases - from past achievements to future challenges.- DNA and RNA pyrimidine nucleobase alkylation at the carbon-5 position.- Bacterial DNA methylation and methylomes.- Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases.- Enzymology of mammalian DNA methyltransferases.- Genetic studies on mammalian DNA methyltransferases.- The role of DNA methylation in cancer.- Structure and mechanism of plant DNA methyltransferases.- DNA methylation and gene regulation in honey bees: from genome-wide analyses to obligatory epi-alleles.- N6-methyladenine: a conserved and dynamic DNA mark.- Pathways of DNA demethylation.- Structure and function of TET enzymes.- Proteins that read DNA methylation.- DNA base flipping - a general mechanism for writing, reading, and erasing DNA modifications.- Current and emerging technologies for the analysis of the genome-wide and locus-specific DNA methylation patterns.- DNA methyltransferase inhibitors - development and applications.- Rewriting DNA methylation signatures at will: the curable genome within reach?.- Engineering and directed evolution of DNA methyltransferases.- DNA labeling using DNA methyltransferases.

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• Biologia Celular (citologia)
• Genética (não médica)

DNA methylation;Epigenetics;Methyltransferase;Demethylation;DNA labelling;Cancer;Therapeutic targets;control of gene expression;Chromatin;Genome imprinting;Epigenetic editing;Cellular memory;Biomarkers;Reader proteins;Emerging technologies;gene expression;cytogenetics