Cellular Ageing and Replicative Senescence

Preface.- Section I History and origins.- Origins of the Hayflick system, the phenomenon and the limit.- Early testing and development of the Hayflick system.- Section II Serial passaging and progressive changes.- Slowing down of the cell cycle.- Ageing of cells in the centenarians and long-lived .- Aging of the stem cells.- Aging and senescence in the immune cells in vitro and in vivo.- Accelerated cellular aging in progeroid syndromes.- Telomere and genomic instability.- Mechanistic explanation for cellular aging in vitro: the commitment theory.- Modelling cellular aging senescence.- Section-III Regulation, and senescence.- Cell cycle checkpoints and regulators of senescence.- Oxidative stress and cellular ageing.- Biomarkers of replicative senescence revisited.- Cellular aging and tumour regulation.- Declining Protein turnover and degradation.- Section IV Modulating the system.- Stress induced premature senescence (SIPS).- Mild stress-induced hormesis.- Food, hormones and growth factors in cellular aging.- sncRNAs in cellular aging and senescence.- Elimination of senescent cells for rejuvenation.- Section-V RECAPITULATION.- The past, present and the future of cellular aging and replicative senescence.- Index.

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• Biologia Celular (citologia)
• Medicina geriátrica
• Genética (não médica)

Ageing;Cancer;Cell cycle regulation;Longevity;Stress;cytogenetics