Clinician's Guide to Sperm DNA and Chromatin Damage

Sperm Chromatin: An Overview.- Sperm Nucleoproteins (Histones and Protamines).- Sperm Nuclear Architecture.- Sperm Chromatin Structure Assay (SCSA (R)): Evolution from Origin to Clinical Utility.- TUNEL Assay.- TUNEL Assay by Bench Top Flow Cytometer in Clinical Laboratories.- The Comet Assay.- Sperm Chromatin Dispersion (SCD) Assay.- Cytochemical Tests of Sperm Chromatin Maturity.- Is There an Optimal Sperm DNA Test?.- Oxidative Stress.- Apoptosis in Ejaculated Spermatozoa and in the Normal and Pathological Testes: Abortive Apoptosis and Sperm Chromatin Damage.- Defective Spermatogenesis and Sperm DNA Damage.- Sperm Chromatin and Lifestyle Factors.- Cancer and Sperm DNA Damage.- Sperm Chromatin and Environmental Factors.- Sperm DNA Damage and Oocyte Repair Capability.- Experimental Studies on Sperm DNA Fragmentation and Reproductive Outcomes.- Sperm DNA and Natural Pregnancy.- Sperm DNA and ART (IUI, IVF, ICSI) Pregnancy.- Sperm DNA and Pregnancy Loss after IVF and ICSI.- Sperm DNA Tests are Clinically Useful: Pro.- Sperm DNA Tests Are Clinically Useful: CON.- Antioxidant Therapy.- Varicocelectomy.- Physiological Intra-Cytoplasmic Sperm Insemination Based on Hyaluronic Acid Binding Ability.- Advanced Sperm Processing / Selection Techniques.- Use of Testicular Sperm for ICSI: Pro.- Debate on the Use of Testicular Sperm for ICSI: Con.- Strategies to Diminish DNA Damage in Sperm Samples used for ART.- Sperm DNA Testing: Where Do We Go from Here?

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• Urologia e medicina urológica
• Endocrinologia
• Infertilidade e fertilização

Abortive apoptosis;Antioxidant therapy;Azoospermia;Comet assay;Cryopreservation;Erectile dysfunction;Gonadotropin;ICSI;Male infertility;Oxidative stress;PICSI-HA binding;SCD assay;SCS assay;Semen analysis;Sperm chromatin;Sperm DNA damage;Sperm nucleoproteins;Testicular dysfunction;TUNEL assay;Varicocelectomy